Potassium Hydroxide → 1-Ethynyl-4-propylbenzene

HRID 493031

반응식

HRID 493031 반응식
[OH-].[K+].[CH2:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][Si](C)(C)C)=[CH:8][CH:7]=1)[CH2:4][CH3:5]>CO>[CH2:3]([C:6]1[CH:7]=[CH:8][C:9]([C:12]#[CH:13])=[CH:10][CH:11]=1)[CH2:4][CH3:5]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 193534011-(4-n-Propylphenyl)-2-trimethylsilylacetylene

생성물 1

HCID 27751331-Ethynyl-4-propylbenzene수율 99.4%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

Methanol (150 ml) and an aqueous solution of 1N-potassium hydroxide (100 ml) were added to 14.2 g (65.7 mmol) of 1-(4-n-propylphenyl)-2-trimethylsilylacetylene synthesized in the step (i), and the mixture was subjected to hydrolysis with vigorously stirring overnight. After completion of the reaction, methanol was removed and the resultant residue was extracted with hexane. After removing hexane from the hexane phase, the resultant residue was washed with water to give 9.4 g (65.3 mmol) of 4-n-propylphenylacetylene.

후처리

  1. customsynthesized in the step (i)
  2. customthe mixture was subjected to hydrolysis
  3. customwas removed
  4. extractionthe resultant residue was extracted with hexane
  5. customAfter removing hexane from the hexane phase
  6. washthe resultant residue was washed with water

출처 및 근거

ORD 기록
ord-b6c976575fa84c26b28100f46a3d5f38
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534547B2

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