Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propofol → 2-(Chloromethoxy)-1,3-diisopropylbenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propofol | HCID 4943 | — |
| 반응물 | Bromochloromethane | HCID 6333 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(Chloromethoxy)-1,3-diisopropylbenzene | HCID 11253147 | 85% |
반응 단계
2,6-diisopropylphenol was treated with bromochloromethane in the presence of sodium hydroxide and THF to give an 85% yield of O-chloromethyl-2,6-diisopropylphenol, which was purified by vacuum distillation. Treatment of O-chloromethyl-2,6-diisopropylphenol with phosphoric acid and triethylamine in acetonitrile followed by solvent removal, dissolution in methanol, pH adjustment and precipitation with acetone gave an 85% yield of phosphono-O-methyl 2,6-diisopropylphenol disodium salt.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07534776B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-1e7971a0d38a49eca606ccc4d2e6707b |
| 출처 메모 | uspto-grants-2009_05 |