Ethyl Acetate → ethyl 4,7-difluoro-1H-indole-2-carboxylate

반응식

[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:12]=[O:13])[NH:6]2.[C:14](OCC)(=[O:16])[CH3:15]>>[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH:4]=[C:5]([C:12]([O:16][CH2:14][CH3:15])=[O:13])[NH:6]2

참가 물질

반응물 2

HCID 8857Ethyl Acetate

HCID 22281717HCID 22281717, 화합물

생성물 1

HCID 22281774ethyl 4,7-difluoro-1H-indole-2-carboxylate

실험 절차

The cooled mixture was dissolved in ethyl acetate, washed with sodium bicarbonate and brine, dried and evaporated. Chromatography on silica gel (1:1 dichloromethane/petrol) followed by recrystallization (dichloromethane/hexane) gave the indole ester (0.75 g). (f) 4,7-Difluoroindole-2-carboxaldehyde

후처리

washwashed with sodium bicarbonate and brine
customdried
customevaporated
customChromatography on silica gel (1:1 dichloromethane/petrol) followed by recrystallization (dichloromethane/hexane)
customgave the indole ester (0.75 g)

출처 및 근거

ORD 기록: ord-dd3df5976fb640cbaad59042b33b9d69
출처 데이터셋: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07534793B2

반응 노트

불러오는 중…