Sodium Iodide → HCID 20636318, 화합물

HRID 49329

반응식

HRID 49329 반응식
CS([O:5][CH2:6][C:7]1[S:8][C:9]([C:12]2([CH2:17][CH3:18])[O:16][CH2:15][CH2:14][O:13]2)=[CH:10][CH:11]=1)(=O)=O.O[C:20]1[CH:21]=[C:22]([C:30]([O:32][CH3:33])=[O:31])[C:23](=[CH:28][CH:29]=1)[C:24]([O:26][CH3:27])=[O:25].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>CC(=O)CC>[CH2:17]([C:12]1([C:9]2[S:8][C:7]([CH2:6][O:5][C:29]3[CH:28]=[C:23]([C:24]([O:26][CH3:27])=[O:25])[C:22](=[CH:21][CH:20]=3)[C:30]([O:32][CH3:33])=[O:31])=[CH:11][CH:10]=2)[O:16][CH2:15][CH2:14][O:13]1)[CH3:18]

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 89726Dimethyl 4-hydroxyphthalateHCID 206363015-(2-Ethyl-[1,3]dioxolan-2-yl)-2-thienylmethyl methanesulphonate

생성물 1

HCID 20636318HCID 20636318, 화합물

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

9.25 g (43.2 mmol) of 5-(2-ethyl-[1,3]dioxolan-2-yl)-2-thienylmethyl methanesulphonate are dissolved in 100 mL of 2-butanone, and 9.07 g (43.2 mmol) of dimethyl 4-hydroxyphthalate (prepared in Example 1(b)), 6 g of potassium carbonate (43.2 mmol) and 20 mg of sodium iodide are added. The mixture is refluxed for 12 hours, cooled and filtered. The filtrate is concentrated under reduced pressure and then purified by chromatography on a column of silica. A yellow oil is obtained (m=12.70 g; Y=73%).

후처리

  1. temperatureThe mixture is refluxed for 12 hours
  2. temperaturecooled
  3. filtrationfiltered
  4. concentrationThe filtrate is concentrated under reduced pressure
  5. custompurified by chromatography on a column of silica
  6. customA yellow oil is obtained (m=12.70 g; Y=73%)

출처 및 근거

ORD 기록
ord-3398eeb0de564ba9ab1b8cc49873e73a
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706725B1

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