Sodium Methoxide → HCID 22036378, 화합물

HRID 493343노트

반응식

HRID 493343 반응식
Br[C:2]1[C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O-:13].[Na+]>CO>[OH:11][CH2:10][CH2:9][O:8][C:7]1[C:2]([O:13][CH3:12])=[N:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 220362632-[(2-Bromopyridin-3-yl)oxy]ethan-1-ol

생성물 1

HCID 22036378HCID 22036378, 화합물수율 45%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of the product obtained in Step 1 (2.33 g, 10.7 mmol) and NaOMe (0.634 mg, 11.8 mmol) in MeOH (50 mL) was refluxed overnight. The reaction mixture was filtered and concentrated. The residue was purified by column chromatography on silica, using CH2Cl2/MeOH/heptane (4:1:5) as eluent, to give 0.81 g (45%) of the title compound as a colorless oil.

후처리

  1. temperaturewas refluxed overnight
  2. filtrationThe reaction mixture was filtered
  3. concentrationconcentrated
  4. customThe residue was purified by column chromatography on silica

출처 및 근거

ORD 기록
ord-1a337cf3feb846ebb87aea87a91c5cbb
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534794B2

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