Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(4-Bromo-2-thienyl)-1-propanol → 4-Bromo-2-propionylthiophene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(4-Bromo-2-thienyl)-1-propanol | HCID 22606901 | — |
| 촉매 | HCID 178418406 | HCID 178418406 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Bromo-2-propionylthiophene | HCID 818932 | — |
반응 단계
33.5 g (151 mmol) of 1-(4-bromo-2-thienyl)-1-propanol are dissolved in 400 mL of dichloromethane. 130 g (1.5 mol) of manganese dioxide are then added portionwise and the medium is stirred at room temperature for 24 hours. After filtration through Celite and then concentration and chromatography on silica gel (eluent: 9 heptane/1 ethyl acetate), the desired product is obtained in the form of white crystals (m=26.6 g; Y=80%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06706725B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-5d27fd9b2e004ef1b5d56e425461e493 |
| 출처 메모 | uspto-grants-2004_03 |