Water → 4-[4-(Aminomethyl)phenyl]phenol

HRID 493470노트

반응식

HRID 493470 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3].O.[OH-].[K+]>C1COCC1>[NH2:15][CH2:14][C:11]1[CH:10]=[CH:9][C:8]([C:5]2[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=2)=[CH:13][CH:12]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14797Potassium HydroxideHCID 1406104'-Hydroxy-4-biphenylcarbonitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 162278894-[4-(Aminomethyl)phenyl]phenol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

4′-Hydroxy-biphenyl-4-carbonitrile (10.00 g, 51.2 mmol) in 150 mL of anhydrous THF was added under nitrogen dropwise over 30 minutes to a suspension of LAH (2.91 g, 76.7 mmol) in 200 mL of anhydrous THF at room temperature. After the addition the reaction was refluxed for 20 h (overnight). In the following order 2.91 mL of water, 2.91 mL of 15% KOH and 8.73 mL of water were added dropwise. The reaction was stirred for 30 minutes at room temperature. The solid was removed by filtration and dried under reduced pressure to give a yellow solid which was used in the next step without additional purification.

후처리

  1. additionAfter the addition the reaction
  2. temperaturewas refluxed for 20 h (overnight)
  3. customThe solid was removed by filtration
  4. customdried under reduced pressure
  5. customto give a yellow solid which
  6. customwas used in the next step without additional purification

출처 및 근거

ORD 기록
ord-64c0b4c6376a40d98a50ab2ae3eb2a7e
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534894B2

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