Triethylamine (275 μL, 1.97 mmol) was added under nitrogen to a mixture of 1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carbonyl chloride (272 mg, 0.992 mmol) and 4′-methoxycarbonylmethoxy-biphenyl-4-ylmethyl-ammonium; chloride (304 mg, 0.986 mmol), prepared in the previous step, in 20 mL of methylene chloride at room temperature. The reaction was stirred at room temperature for 6 h. The reaction was extracted with water, 5% NaHCO3, dried (MgSO4) and the solvent removed under reduced pressure to give methyl({4′-[({[1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}amino)methyl][1,1′-biphenyl]-4-yl}oxy)acetate (508 mg, 100%) as a white solid, mp 174-176° C. Elemental Analysis for C27H22F3N3O4+0.07 CH2Cl2. Calc'd C, 63.08; H, 4.33; N, 8.15. Found: C, 63.01; H, 4.17; N, 8.16.
