참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 2,5-Dichloropyridine-3-carboxylic acid | HCID 2736085 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 2,5-dichloronicotinate | HCID 5200405 | — |
반응 단계
To a solution of 2,5-dichloronicotinic acid (30 g, 0.16 mol) in toluene (100 ml) was added ethanol (50 ml) and conc. sulfuric acid (1 ml). The reaction mixture was heated at 130° C. for 3 days with stirring. Then the reaction mixture was cooled and poured into sat. sodium bicarbonate solution. The whole mixture was extracted with ethyl acetate. The organic phase was washed with brine, dried (sodium sulfate), and concentrated to afford 34 g (quant.) of title compound:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07534914B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_05 |
|---|
| ORD ID | ord-3991b91846c94e3bb9581a3fdd1b60eb |
|---|
| 출처 메모 | uspto-grants-2009_05 |
|---|
