2-oxo-3-(1-benzylpiperidin-4-yl)-2,3-dihydro-1H-imidazo[4,5-c]pyridine → 2-Oxo-3-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-c]pyridine

HRID 493585

반응식

HRID 493585 반응식
[O:1]=[C:2]1[N:10]([CH:11]2[CH2:16][CH2:15][N:14](CC3C=CC=CC=3)[CH2:13][CH2:12]2)[C:5]2[CH:6]=[N:7][CH:8]=[CH:9][C:4]=2[NH:3]1>CO.[OH-].[OH-].[Pd+2]>[O:1]=[C:2]1[N:10]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:5]2[CH:6]=[N:7][CH:8]=[CH:9][C:4]=2[NH:3]1

참가 물질

4

반응물 1

HCID 222931702-oxo-3-(1-benzylpiperidin-4-yl)-2,3-dihydro-1H-imidazo[4,5-c]pyridine

생성물 1

HCID 222931682-Oxo-3-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-c]pyridine수율 85.9%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

A solution of 2-oxo-3-(1-benzylpiperidin-4-yl)-2,3-dihydro-1H-imidazo[4,5-c]pyridine (0.5 g, 1.6 mmol) in methanol (250 mL) was shaken with 20% Pd(OH)2 under a hydrogen atmosphere for 48 h at room temperature. The reaction was filtered and concentrated to give the title compound as a white solid (0.3 g). MS 219 (M+1).

후처리

  1. filtrationThe reaction was filtered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1a0adc6a5c2b4f5ba691e23c70bce8ee
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534784B2

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