Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,5-Diaminopyrimidine → 4-Amino-5-[(1-t-butoxycarbonylpiperidin-4-yl)amino)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,5-Diaminopyrimidine | HCID 83703 | — |
| 반응물 | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | 4-Amino-5-[(1-t-butoxycarbonylpiperidin-4-yl)amino)pyrimidine | HCID 22293202 | — |
반응 단계
A mixture of 4,5-diaminopyrimidine (1.0 g, 9.1 mmol), N-(t-butoxycarbonyl)-4-piperidone (3.0 g, 15 mmol) and sodium triacetoxyborohydride (1.2 g, 5.6 mmol) in dichloroethane (60 mL) was stirred at room temperature for 3 d. The reaction was partitioned between chloroform (200 mL) and 3N sodium hydroxide (30 mL). After drying over magnesium sulfate, the organic phase was concentrated to give the title compound as a tan gum. MS 294 (M+1)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07534784B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-9e97fb913b8e49cb9bacbe9a0c586c63 |
| 출처 메모 | uspto-grants-2009_05 |