1-Tetralone → 5-Nitro-3,4-dihydronaphthalen-1(2H)-one
반응식
[CH2:1]1[CH2:11][C:9](=[O:10])[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2]1.[N+:12]([O-])([O-:14])=[O:13].[K+]>S(=O)(=O)(O)O.CCOCC>[CH2:1]1[CH2:11][C:9](=[O:10])[C:8]2[CH:7]=[CH:6][CH:5]=[C:4]([N+:12]([O-:14])=[O:13])[C:3]=2[CH2:2]1참가 물질
5
실험 절차
10 ml (75 mmol) of α-tetralone was added dropwise to 7.6 g (75 mmol) of potassium nitrate dissolved in 75 ml of concentrated sulfuric acid (at -10° C.). The resulting mixture was poured onto ice and the precipitate was suspended in ether. The precipitate (the 7 nitro isomer) was filtered off and the ether solution was evaporated. The residue was purified by column chromatography on silica gel. Yield: 4.7 g of the title compound, M.p. 94°-96° C.
후처리
- additionThe resulting mixture was poured onto ice
- filtrationThe precipitate (the 7 nitro isomer) was filtered off
- customthe ether solution was evaporated
- customThe residue was purified by column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-daf799bbc7ae46a8bc6b98336a253489
- 출처 데이터셋
- uspto-grants-1993_09
- 특허 번호
- US05242918
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