1-Tetralone → 5-Nitro-3,4-dihydronaphthalen-1(2H)-one

HRID 4936

반응식

HRID 4936 반응식
[CH2:1]1[CH2:11][C:9](=[O:10])[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2]1.[N+:12]([O-])([O-:14])=[O:13].[K+]>S(=O)(=O)(O)O.CCOCC>[CH2:1]1[CH2:11][C:9](=[O:10])[C:8]2[CH:7]=[CH:6][CH:5]=[C:4]([N+:12]([O-:14])=[O:13])[C:3]=2[CH2:2]1

참가 물질

5

반응물 2

HCID 107241-TetraloneHCID 24434Potassium Nitrate

생성물 1

HCID 102619465-Nitro-3,4-dihydronaphthalen-1(2H)-one

시약·촉매·용매 2

HCID 1118Sulfuric Acid용매HCID 3283Diethyl Ether용매

실험 절차

10 ml (75 mmol) of α-tetralone was added dropwise to 7.6 g (75 mmol) of potassium nitrate dissolved in 75 ml of concentrated sulfuric acid (at -10° C.). The resulting mixture was poured onto ice and the precipitate was suspended in ether. The precipitate (the 7 nitro isomer) was filtered off and the ether solution was evaporated. The residue was purified by column chromatography on silica gel. Yield: 4.7 g of the title compound, M.p. 94°-96° C.

후처리

  1. additionThe resulting mixture was poured onto ice
  2. filtrationThe precipitate (the 7 nitro isomer) was filtered off
  3. customthe ether solution was evaporated
  4. customThe residue was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-daf799bbc7ae46a8bc6b98336a253489
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242918

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