Potassium Carbonate → HCID 178482552, 화합물

HRID 493698

반응식

HRID 493698 반응식
[CH3:1][N:2]1[C:6]([CH3:7])=[C:5]([C:8]([OH:10])=O)[S:4]/[C:3]/1=[N:11]\[CH3:12].[Cl:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[C:19]([S:24]([CH2:27][CH2:28][C:29]([N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)=[O:30])(=[O:26])=[O:25])[CH:18]=[CH:17]2.C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.C(=O)([O-])[O-].[K+].[K+]>ClCCl.C(N(CC)CC)C>[Cl:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[C:19]([S:24]([CH2:27][CH2:28][C:29]([N:31]1[CH2:32][CH2:33][N:34]([C:8]([C:5]3[S:4]/[C:3](=[N:11]\[CH3:12])/[N:2]([CH3:1])[C:6]=3[CH3:7])=[O:10])[CH2:35][CH2:36]1)=[O:30])(=[O:26])=[O:25])[CH:18]=[CH:17]2

참가 물질

8

반응물 5

HCID 11430Potassium CarbonateHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 231308831-(3-((6-Chloro-2-naphthyl)sulfonyl)propionyl)piperazineHCID 178482553HCID 178482553, 화합물

생성물 1

HCID 178482552HCID 178482552, 화합물수율 8.9%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8471Triethylamine용매

실험 절차

(2Z)-3,4-Dimethyl-2-methylimino-2,3-dihydro-1,3-thiazole-5-carboxylic acid (0.6 g) was dissolved in dichloromethane (30 mL), and triethylamine (0.14 mL) was added thereto. With ice cooling, 1-(3-((6-chloro-2-naphthyl)sulfonyl)propionyl)piperazine (1.0 g), HOBt (0.42 g) and WSC (0.57 g) were added thereto, and the mixture was mixed at room temperature for 16 hours. The reaction solution was basified with an aqueous potassium carbonate solution, then extracted with chloroform, and the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified with a basic silica gel column to give the title compound (0.13 g) as a white powder.

후처리

  1. additionthe mixture was mixed at room temperature for 16 hours
  2. extractionextracted with chloroform
  3. dry with materialthe extract was dried over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off
  5. customthe residue was purified with a basic silica gel column

출처 및 근거

ORD 기록
ord-c46f2e1a308a4935b48dc3efa5d19905
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534887B2

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