1,4-Cyclohexadiene → 2-[4-(4-Methyl-oxazol-2-yl)-phenoxy]-ethylamine

HRID 49373

반응식

HRID 49373 반응식
C(OC(=O)[NH:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[O:21][CH:22]=[C:23]([CH3:25])[N:24]=2)=[CH:16][CH:15]=1)C1C=CC=CC=1.C1CC=CCC=1>CO.[Pd]>[CH3:25][C:23]1[N:24]=[C:20]([C:17]2[CH:18]=[CH:19][C:14]([O:13][CH2:12][CH2:11][NH2:10])=[CH:15][CH:16]=2)[O:21][CH:22]=1

참가 물질

5

반응물 2

HCID 123431,4-CyclohexadieneHCID 12986049{2-[4-(4-Methyl-oxazol-2-yl)-phenoxy]-ethyl}-carbamic acid benzyl ester2회

생성물 1

HCID 120719972-[4-(4-Methyl-oxazol-2-yl)-phenoxy]-ethylamine수율 90%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

The title compound of Example 1, {2-[4-(4-Methyl-oxazol-2-yl)-phenoxy]-ethyl}-carbamic acid benzyl ester, (166 mg, 0.47 mmol) was dissolved in methanol (5 ml) and 10% Pd/C (50 mg) and 1,4-cyclohexadiene (192 mg, 2.4 mmol) were added to the resulting solution. The mixture was allowed to stir for about sixteen hours, and then it was filtered through diatomaceous earth, and the filter pad was washed with methanol. The filtrate was concentrated in vacuo to dryness, and the resulting material (92 mg, 90% yield), which was determined to be pure by 1H NMR, was used directly without further purification. LRMS ([M+H]+)=219.2.

후처리

  1. filtrationit was filtered through diatomaceous earth
  2. washthe filter pad was washed with methanol
  3. concentrationThe filtrate was concentrated in vacuo to dryness

출처 및 근거

ORD 기록
ord-b8a149b034b44dceb24886fdb7e850f7
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706743B2

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