1-Chloroethyl chloroformate → 6,7,8,9-tetrahydro-1H-pyrrolo[2,3-f]isoquinoline-2,3-dione

HRID 4938

반응식

HRID 4938 반응식
C[N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]3[C:14](=[O:15])[C:13](=[O:16])[NH:12][C:8]3=2)[CH2:3]1.ClC(OC(Cl)=O)C>ClCCCl>[NH:12]1[C:8]2=[C:9]3[C:4](=[CH:5][CH:6]=[C:7]2[C:14](=[O:15])[C:13]1=[O:16])[CH2:3][NH:2][CH2:11][CH2:10]3

참가 물질

4

반응물 2

HCID 5213051-Chloroethyl chloroformateHCID 152882036,7,8,9-tetrahydro-7-methyl-1H-pyrrolo[2,3-f]isoquinoline-2,3-dione

생성물 1

HCID 152882046,7,8,9-tetrahydro-1H-pyrrolo[2,3-f]isoquinoline-2,3-dione

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

To an ice cooled stirred suspension of 6,7,8,9-tetrahydro-7-methyl-1H-pyrrolo[2,3-f]isoquinoline-2,3-dione (500 mg) in 1,2-dichloroethane (10 ml) was added α-chloroethylchloroformate (0.25 ml). The mixture was then brought to reflux for 1 hour, whereafter it was cooled to room temperature and filtered. The filtrate was evaporated, the residue dissolved in methanol (10 ml) and refluxed for 10 min. Evaporation of the solvent left the crude title compound as a solid, M.p. 270° C.

후처리

  1. temperatureto reflux for 1 hour, whereafter it
  2. filtrationfiltered
  3. customThe filtrate was evaporated
  4. dissolutionthe residue dissolved in methanol (10 ml)
  5. temperaturerefluxed for 10 min
  6. customEvaporation of the solvent
  7. waitleft the crude title compound as a solid, M.p. 270° C.

출처 및 근거

ORD 기록
ord-461d95d8d5924dfa90fb02af4201c163
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242918

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