1-Chloroethyl chloroformate → 6,7,8,9-tetrahydro-1H-pyrrolo[2,3-f]isoquinoline-2,3-dione
반응식
C[N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]3[C:14](=[O:15])[C:13](=[O:16])[NH:12][C:8]3=2)[CH2:3]1.ClC(OC(Cl)=O)C>ClCCCl>[NH:12]1[C:8]2=[C:9]3[C:4](=[CH:5][CH:6]=[C:7]2[C:14](=[O:15])[C:13]1=[O:16])[CH2:3][NH:2][CH2:11][CH2:10]3참가 물질
4
실험 절차
To an ice cooled stirred suspension of 6,7,8,9-tetrahydro-7-methyl-1H-pyrrolo[2,3-f]isoquinoline-2,3-dione (500 mg) in 1,2-dichloroethane (10 ml) was added α-chloroethylchloroformate (0.25 ml). The mixture was then brought to reflux for 1 hour, whereafter it was cooled to room temperature and filtered. The filtrate was evaporated, the residue dissolved in methanol (10 ml) and refluxed for 10 min. Evaporation of the solvent left the crude title compound as a solid, M.p. 270° C.
후처리
- temperatureto reflux for 1 hour, whereafter it
- filtrationfiltered
- customThe filtrate was evaporated
- dissolutionthe residue dissolved in methanol (10 ml)
- temperaturerefluxed for 10 min
- customEvaporation of the solvent
- waitleft the crude title compound as a solid, M.p. 270° C.
출처 및 근거
- ORD 기록
- ord-461d95d8d5924dfa90fb02af4201c163
- 출처 데이터셋
- uspto-grants-1993_09
- 특허 번호
- US05242918
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