돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 493986생성일: 2026년 10월 25일

Lithium Chloride → (1,1-Dioxo-thiomorpholin-4-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

https://huagongshe.com/reaction/493986

반응식

참여 물질

역할이름HCID투입량
반응물Lithium ChlorideHCID 433294—
반응물Thiomorpholine 1,1-dioxideHCID 6484228—
반응물5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acidHCID 59699456—
생성물(1,1-Dioxo-thiomorpholin-4-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanoneHCID 16739577—

반응 단계

In analogy to the procedure described for the synthesis of example 1, step 3, the title compound was synthesized from 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid hydrochloric salt with one equivalent of lithium chloride (example 2, step 1) and thiomorpholine-1,1-dioxide (purchased at Syntec, ref. M1201). The title product was obtained in 75% yield as white solid. MS (m/e): 420.5 (MH+, 100%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07538101B2
출처 데이터셋uspto-grants-2009_05
ORD IDord-2a72d450256e4b5bb8a0f2c6e6d152c0
출처 메모uspto-grants-2009_05