(+-)-Methionine → 4-(1,2-Oxazol-4-yl)phenol

HRID 49401

반응식

HRID 49401 반응식
NC(C(O)=O)CCSC.C[O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]=[N:20][O:21][CH:22]=2)=[CH:14][CH:13]=1.CS(O)(=O)=O>>[O:21]1[CH:22]=[C:18]([C:15]2[CH:14]=[CH:13][C:12]([OH:11])=[CH:17][CH:16]=2)[CH:19]=[N:20]1

참가 물질

4

반응물 3

HCID 876(+-)-MethionineHCID 6395Methanesulfonic AcidHCID 185236724-(4-Methoxyphenyl)-1,2-oxazole

생성물 1

HCID 185236244-(1,2-Oxazol-4-yl)phenol수율 68.2%

반응 조건

온도
70 °C

실험 절차

To a round-bottomed flask was added D,L-methionine (1.30 g, 8.73 mmol), 4-(4-methoxy-phenyl)-isoxazole (1.02 g, 5.82 mmol), and methanesulfonic acid (24 ml). The resulting solution was heated to about 70° C. for about eighteen hours, and was then allowed to cool to room temperature and poured onto ice water. The mixture was adjusted to about pH 4, and the heterogenous mixture was filtered. The solid was washed with water and then dried to yield the title compound as an off-white solid (640 mg, 68% yield). LRMS ([M−H]−)=160.0.

후처리

  1. temperatureto cool to room temperature
  2. additionpoured onto ice water
  3. filtrationthe heterogenous mixture was filtered
  4. washThe solid was washed with water
  5. customdried

출처 및 근거

ORD 기록
ord-65563c80684040c5aa909fa93bd0af8f
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706743B2

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