Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 4-(Bis(4-chlorophenyl)methyl)piperazin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4,4'-Dichlorobenzhydryl chloride | HCID 13078 | — |
| 반응물 | Piperazin-2-one | HCID 231360 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-(Bis(4-chlorophenyl)methyl)piperazin-2-one | HCID 68931779 | 83.5% |
반응 단계
To a solution of chlorobis(4-chlorophenyl)methane (407 mg, 1.5 mmol) in MeCN was added piperazin-2-one (601 mg, 6.0 mmol) followed by triethylamine (626 μl, 4.5 mmol) and the resulting mixture was refluxed overnight. After cooling to rt, the solvent was evaporated to dryness and the residue was submitted to column chromatography (SiO2, DCM to DCM/MeOH=100:5) to give 4-(bis(4-chlorophenyl)methyl)piperazin-2-one (420 mg) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07538114B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-27f77bb0ef1241de99bd80c85f018621 |
| 출처 메모 | uspto-grants-2009_05 |