Ethylamine → (CH3)3Coc(O)nhch2C(O)nhch2CH3

HRID 494121노트

반응식

HRID 494121 반응식
[CH2:1]([NH2:3])[CH3:2].CO[C:6](=[O:16])[CH2:7][NH:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]>>[C:12]([O:11][C:9]([NH:8][CH2:7][C:6]([NH:3][CH2:1][CH3:2])=[O:16])=[O:10])([CH3:13])([CH3:14])[CH3:15]

참가 물질

3

반응물 2

HCID 6341EthylamineHCID 637609N-Boc-glycine methyl ester

생성물 1

HCID 57248348(CH3)3Coc(O)nhch2C(O)nhch2CH3

실험 절차

Ethylamine (37 g, 0.82 mol) was condensed into a pressure vessel at 0° C. N-(tert-butoxycarbonyl)glycine methyl ester (50 mL, 0.34 mol) was added. The vessel was sealed and the mixture was stirred at room temperature overnight. The product mixture was concentrated under vacuum and the residue was passed through a pad of silica gel eluting with ethyl acetate. The solution was concentrated under vacuum to provide the title compound as a clear oil.

후처리

  1. customcondensed into a pressure vessel at 0° C
  2. customThe vessel was sealed
  3. concentrationThe product mixture was concentrated under vacuum
  4. concentrationThe solution was concentrated under vacuum

출처 및 근거

ORD 기록
ord-b7f176b77d0a48b7bec71e30620c4bd3
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538112B2

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