7-Amino-2-methyl-1,2,3,4-tetrahydroquinoline → 2-Methylquinolin-7-amine
반응식
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH:8]([CH3:12])[NH:9]2)=[CH:4][CH:3]=1>C1(C)C(C)=CC=CC=1.[Pd]>[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[CH:4][CH:3]=1참가 물질
4
실험 절차
A mixture of 7-amino-2-methyl-1,2,3,4-tetrahydroquinoline (D65) (86 mg) and wet 10% palladium/charcoal (25 mg) in xylene (20 ml) was heated at reflux for 3.5 h. After cooling to room temperature the catalyst was removed via filtration and washed with further xylene. Evaporation of the combined filtrate and washings gave the title compound as a crude off-white solid (87 mg) which was used in the next step without further purification. 1H NMR (400 MHz, CDCl3) δ (ppm): 7.87 (d, 1H), 7.56 (d, 1H), 7.14 (d, 1H), 7.03 (d, 1H), 6.91 (dd, 1H), 4.02 (br, 2H), 2.67 (s, 3H).
후처리
- temperaturewas heated
- temperatureat reflux for 3.5 h
- customwas removed via filtration
- washwashed with further xylene
- customEvaporation of the combined filtrate and washings
출처 및 근거
- ORD 기록
- ord-5d6e37a89b3c45379690756bddf6c78f
- 출처 데이터셋
- uspto-grants-2009_05
- 특허 번호
- US07538121B2
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