Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 6-(4-Fluorophenyl)-2-(methoxymethyl)nicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | Ethyl 6-(4-fluorophenyl)-2-(bromomethyl)nicotinate | HCID 69039595 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-(4-Fluorophenyl)-2-(methoxymethyl)nicotinic acid | HCID 69038801 | 66.1% |
반응 단계
Ethyl 6-(4-fluorophenyl)-2-(bromomethyl)nicotinate (D85) (38 mg, 0.11 mmol) was treated with sodium methoxide (18 mg, 0.34 mmol) in methanol (1 ml) at room temperature for 1 h. 2M Sodium hydroxide solution was then added and the solution stirred for 1 h. The mixture was diluted with water and extracted with EtOAc which was dried over MgSO4 and concentrated in vacuo to give the title compound as a white solid (19 mg). MS(ES): MH+ 262, M-H+ 260.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07538121B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-bbffa6218ca04ef2894d1ff9878776a1 |
| 출처 메모 | uspto-grants-2009_05 |