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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 494230생성일: 2026년 10월 26일

2-Methyl-6-(3-fluorophenyl)-nicotinic acid → 6-(3-Fluorophenyl)-2-methyl-N-(1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide

https://huagongshe.com/reaction/494230

반응식

참여 물질

역할이름HCID투입량
반응물2-Methyl-6-(3-fluorophenyl)-nicotinic acidHCID 69039601—
반응물1-(7-Amino-3,4-dihydroquinolin-1(2H)-yl)-2,2,2-trifluoroethanoneHCID 82048422—
생성물6-(3-Fluorophenyl)-2-methyl-N-(1,2,3,4-tetrahydroquinolin-7-yl)nicotinamideHCID 57682683—

반응 단계

Using the procedure outlined in Example 38, the title compound was prepared from 7-amino-1-trifluoroacetyl-1,2,3,4-tetrahydroquinoline (D5) (48 mg, 0.20 mmol) and 2-methyl-6-(3-fluorophenyl)-nicotinic acid (D25) (50 mg, 0.22 mmol) as an off-white solid. MS(ES): MH+ 362, M-H+ 360.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07538121B2
출처 데이터셋uspto-grants-2009_05
ORD IDord-7f1f1831da97479b99f231ed0f84c38b
출처 메모uspto-grants-2009_05