Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorophenylboronic acid → 6-(4-Chlorophenyl)-N-quinolin-7-yl-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorophenylboronic acid | HCID 74299 | — |
| 반응물 | 6-Chloro-N-quinolin-7-yl-nicotinamide | HCID 44578987 | — |
| 생성물 | 6-(4-Chlorophenyl)-N-quinolin-7-yl-nicotinamide | HCID 44578936 | — |
반응 단계
Using the procedure outlined in Example 100, the title compound was prepared from 6-chloro-N-quinolin-7-yl-nicotinamide (D70) (40 mg, 0.14 mmol) and 4-chlorophenylboronic acid (27 mg, 0.17 mmol) as a pale yellow solid. 1H NMR (250 MHz, CDCl3) δ (ppm): 9.25 (dd, 1H), 8.82 (dd, 1H), 8.43 (dd, 1H), 8.33 (dd, 1H), 8.22 (br.d, 1H), 8.11 (d, 1H), 8.00 (d, 2H), 7.89 (d, 1H), 7.87 (d, 1H), 7.51 (d, 2H), 7.40 (dd, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07538121B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-40decab9890040e8b2cdde5495dd00b9 |
| 출처 메모 | uspto-grants-2009_05 |