7-Aminoquinoline → 4-(2-Methylthiazol-4yl)-N-quinolin-7-yl-benzamide

반응식

[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=2)[N:17]=1>>[CH3:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([NH:1][C:2]3[CH:11]=[C:10]4[C:5]([CH:6]=[CH:7][CH:8]=[N:9]4)=[CH:4][CH:3]=3)=[O:23])=[CH:20][CH:19]=2)[N:17]=1

참가 물질

반응물 2

HCID 113777-Aminoquinoline

HCID 6549804-(2-Methyl-1,3-thiazol-4-yl)benzoic acid

생성물 1

HCID 576826654-(2-Methylthiazol-4yl)-N-quinolin-7-yl-benzamide

실험 절차

Using the procedure outlined in Example 56, the title compound was prepared from 7-aminoquinoline (D55) (27 mg, 0.19 mmol) and 4-(2-methylthiazol-4-yl)-benzoic acid (D87) (50 mg, 0.23 mmol) as a solid. MS(ES): MH+ 346, M-H+ 344

출처 및 근거

ORD 기록: ord-b91ac506029846fd96a4211541561e39
출처 데이터셋: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07538121B2

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