Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → HCID 57682666, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Methyl-6-(3,4-difluorophenyl)nicotinic acid | HCID 69038091 | — |
| 반응물 | 1-(7-Amino-3,4-dihydroquinolin-1(2H)-yl)-2,2,2-trifluoroethanone | HCID 82048422 | — |
| 생성물 | HCID 57682666 | HCID 57682666 | — |
반응 단계
Using the procedure outlined in Example 38, the title compound was prepared from 7-amino-1-trifluoroacetyl-1,2,3,4-tetrahydroquinoline (D5) (73 mg, 0.30 mmol) and 2-methyl-6-(3,4-difluorophenyl)nicotinic acid (D108) (82 mg, 0.33 mmol) then converted to the HCl salt as a buff solid. 1H NMR (400 MHz, DMSO) δ (ppm): 8.23 (dd, 1H), 8.04 (m, 3H), 7.87 (d, 1H), 7.63 (d, 1H), 7.57 (m, 1H), 7.29 (d, 1H), 3.34 (m, 2H), 2.80 (m, 2H), 2.67 (s, 3H), 2.02 (m, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07538121B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-4abc59f5ba0f4b5baba4d153fbaa52ee |
| 출처 메모 | uspto-grants-2009_05 |