Ethanol → Ethyl 5-chloro-2-nitrobenzoate

HRID 494410

반응식

HRID 494410 반응식
[CH2:1]([OH:3])[CH3:2].C(N(CC)CC)C.[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([N+:21]([O-:23])=[O:22])=[C:16]([CH:20]=1)[C:17](Cl)=[O:18].O>O1CCCC1.C(OCC)(=O)C>[CH2:1]([O:3][C:17](=[O:18])[C:16]1[CH:20]=[C:12]([Cl:11])[CH:13]=[CH:14][C:15]=1[N+:21]([O-:23])=[O:22])[CH3:2]

참가 물질

7

반응물 4

HCID 702EthanolHCID 962WaterHCID 8471TriethylamineHCID 27236855-Chloro-2-nitrobenzoyl chloride

생성물 1

HCID 603450Ethyl 5-chloro-2-nitrobenzoate

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8857Ethyl Acetate용매

실험 절차

To a mixture of ethanol (1.23 mL), triethylamine (3.05 mL) and tetrahydrofuran (35 mL) was dropwise added a solution of 5-chloro-2-nitrobenzoic acid chloride (4.44 g) obtained in Example 9-4a) in tetrahydrofuran (10 mL) under ice-cooling. The mixture was stirred at room temperature overnight, and water was then added. The solution was diluted with ethyl acetate, and the organic layer was washed successively with saturated aqueous sodium bicarbonate and saturated brine, dried over sodium sulfate and concentrated to give the title compound (4.43 g) as a pale brown solid.

후처리

  1. temperaturecooling
  2. washthe organic layer was washed successively with saturated aqueous sodium bicarbonate and saturated brine
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bcc03612ef434abd9353db96477337bc
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538140B2

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