Ethanone, 1-(3,5-bis(phenylmethoxy)phenyl)- → 1-(3,5-Bis(phenylmethoxy)phenyl)-2-bromoethan-1-one

HRID 494417

반응식

HRID 494417 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:23](=[O:25])[CH3:24])[CH:12]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br-:26].[Br-].[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1.CO>[CH2:16]([O:15][C:13]1[CH:12]=[C:11]([C:23](=[O:25])[CH2:24][Br:26])[CH:10]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:14]=1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

5

반응물 2

HCID 120098Ethanone, 1-(3,5-bis(phenylmethoxy)phenyl)-HCID 23500184Tetra-n-butylammonium tribromide

생성물 1

HCID 1200971-(3,5-Bis(phenylmethoxy)phenyl)-2-bromoethan-1-one

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매2회

실험 절차

To a stirred solution of 1-[3,5-bis(benzyloxy)phenyl]ethanone (5 g, 15.04 mmol) in tetrahydrofuran (60 mL) and methanol (35 mL) was added tetrabutylammonium tribromide (7.25 g, 15.04 mmol) in tetrahydrofuran (20 mL) at room temperature. The reaction mixture was stirred for 24 hours and the solvent removed in vacuo. The residue was dissolved in ethyl acetate (100 mL) and washed with water (2×50 mL). The combined organic extracts were dried over magnesium sulfate and concentrated to afford the desired compound as a yellow oil in quantitative yield.

후처리

  1. customthe solvent removed in vacuo
  2. dissolutionThe residue was dissolved in ethyl acetate (100 mL)
  3. washwashed with water (2×50 mL)
  4. dry with materialThe combined organic extracts were dried over magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-37b82bc9545047b0916a4cec67c3ded1
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538141B2

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