1-(3-Bromophenyl)propan-2-one → 1-(3-Bromophenyl)-2-methylpropan-2-ol

HRID 494418노트

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HRID 494418 반응식
[CH3:1][Mg]Br.[Br:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12](=[O:14])[CH3:13])[CH:8]=[CH:9][CH:10]=1>C(OCC)C>[Br:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([CH3:1])([OH:14])[CH3:13])[CH:8]=[CH:9][CH:10]=1

참가 물질

4

반응물 2

HCID 27340931-(3-Bromophenyl)propan-2-oneHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 230877121-(3-Bromophenyl)-2-methylpropan-2-ol수율 82.7%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

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온도
0 °C

실험 절차

Methylmagnesium bromide (3M solution in diethylether, 51.6 mL, 155 mmol) was slowly added to a solution of 1-(3-bromo-phenyl)propan-2-one (15.0 g, 70 mmol) in dry diethylether (200 mL) at 0° C. The resulting mixture was left for 3 hours, then cooled to 0° C. and slowly quenched with saturated aqueous ammonium chloride solution. The organic phase was washed with brine and dried (sodium sulfate). The yellow oil was then purified by column chromatography on silica gel eluting with dichloromethane:pentane:methanol (90:5:5 by volume to afford a pale yellow oil (13.26 g).

후처리

  1. customslowly quenched with saturated aqueous ammonium chloride solution
  2. washThe organic phase was washed with brine
  3. dry with materialdried (sodium sulfate)
  4. customThe yellow oil was then purified by column chromatography on silica gel eluting with dichloromethane:pentane:methanol (90:5:5 by volume

출처 및 근거

ORD 기록
ord-770e522bd0d947dfb1bbc17f7ecaf18f
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538141B2

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