Trifluoroacetic acid → Methyl 3-(2-amino-2-methylpropyl)benzoate

HRID 494422노트

반응식

HRID 494422 반응식
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][C:11]([NH:14]C(OC(C)(C)C)=O)([CH3:13])[CH3:12])[CH:5]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][C:11]([NH2:14])([CH3:12])[CH3:13])[CH:5]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 597135613-(2-tert-Butoxycarbonylamino-2-methylpropyl)benzoic acid methyl ester

생성물 1

HCID 57516949Methyl 3-(2-amino-2-methylpropyl)benzoate수율 98.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 3-(2-tert-butoxycarbonylamino-2-methylpropyl)benzoic acid methyl ester (Preparation 20) (1.6 g, 5.2 mmol) in dichloromethane (160 mL) at 0° C. was treated with trifluoroacetic acid (13.6 mL) and left to warm to room temperature over 2 hours. The solvent was removed in vacuo and the product purified by cation exchange chromatography (methanol followed by 2M ammonia in methanol) to yield the title compound as an amber oil (1.06 g).

후처리

  1. waitleft
  2. customThe solvent was removed in vacuo
  3. customthe product purified by cation exchange chromatography (methanol followed by 2M ammonia in methanol)

출처 및 근거

ORD 기록
ord-ed8c687b7deb400d9be455c7c47a6594
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538141B2

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