Diethyl 2-(2-phenyl-2-propylpentanoyl)malonate → Ethyl 1-hydroxy-4,4-dimethyl-3-oxo-3,4-dihydro-2-naphthalenecarboxylate

반응식

[CH3:1][C:2]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([CH3:16])[C:3]([CH:5]([C:11]([O:13]CC)=O)[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[O:4].C1(C(CCC)(CCC)C(C(C(OCC)=O)C(OCC)=O)=O)C=CC=CC=1>>[OH:13][C:11]1[C:18]2[C:17](=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:2]([CH3:16])([CH3:1])[C:3](=[O:4])[C:5]=1[C:6]([O:8][CH2:9][CH3:10])=[O:7]

참가 물질

반응물 2

HCID 11552281Diethyl 2-(2-phenyl-2-propylpentanoyl)malonate

HCID 12369090Diethyl 2-(2-methyl-2-phenylpropanoyl)malonate

생성물 1

HCID 57604805Ethyl 1-hydroxy-4,4-dimethyl-3-oxo-3,4-dihydro-2-naphthalenecarboxylate

실험 절차

The title compound was prepared according to the procedure of Example 1F, substituting the product of Example 9D for the product of Example 1E. 1H NMR (300 MHz, CDCl3): δ 15.16, 15.03 (two s, 1 H), 8.18 (m, 1 H), 7.52 (m, 3 H), 4.47 (m, 2 H), 1.66 (s, 3H), 1.51 (s, 3 H), 1.45 (t, J=6.62 Hz, 3 H).

출처 및 근거

ORD 기록: ord-55c7265aa36c429882581bdc053a8b7d
출처 데이터셋: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07538105B2

반응 노트

불러오는 중…