[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH2:44][CH2:45][CH3:46])([CH2:41][CH2:42][CH3:43])[C:7](=[O:40])[C:8]([C:13]3[NH:18][C:17]4[CH:19]=[CH:20][C:21]([NH:23][S:24]([NH:27]C(=O)OCC5C=CC=CC=5)(=[O:26])=[O:25])=[CH:22][C:16]=4[S:15](=[O:39])(=[O:38])[N:14]=3)=[C:9]2[OH:12])=[CH:4][CH:3]=1>[Pd].CO.C(OCC)(=O)C>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH2:44][CH2:45][CH3:46])([CH2:41][CH2:42][CH3:43])[C:7](=[O:40])[C:8]([C:13]3[NH:18][C:17]4[CH:19]=[CH:20][C:21]([NH:23][S:24]([NH2:27])(=[O:25])=[O:26])=[CH:22][C:16]=4[S:15](=[O:39])(=[O:38])[N:14]=3)=[C:9]2[OH:12])=[CH:4][CH:3]=1A solution of the product of Example 17D (28 mg, 0.042 mmol) in 2:1 methanol-ethyl acetate (15 mL) was treated with 10% Pd/C (20 mg) and hydrogenated at one atmosphere for 18 h. The mixture was filtered through Celite® and the filtrate concentrated in vacuo to afford the title compound (13 mg).
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