Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 49462생성일: 2026년 10월 24일
2-Naphthalenesulfonyl chloride → N-(2-{[(3-Hydroxypropyl)amino]methyl}-3,4-dihydro-2H-chromen-7-yl)naphthalene-2-sulfonamide
https://huagongshe.com/ko/reaction/49462
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Naphthalenesulfonyl chloride | HCID 7125 | — |
| 반응물 | 3-Amino-1-propanol | HCID 9086 | — |
| 반응물 | (7-Aminochroman-2-yl)methanol | HCID 10511549 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | N-(2-{[(3-Hydroxypropyl)amino]methyl}-3,4-dihydro-2H-chromen-7-yl)naphthalene-2-sulfonamide | HCID 10202719 | — |
반응 단계
A solution of (7-amino-3,4-dihydro-2H-chromen-2-yl)methanol (25 mg, 140 μmol) in pyridine is treated with 2-naphthalenesulfonylchloride (70 mg, 308 μmol) at ambient temperature for 1 h, treated with 3-amino-1-propanol (3 mmol, 0.23 mL), heated at 80° C. for 3 h, diluted with water and extracted with ethyl acetate. The extracts are combined, dried over Na2SO4 and concentrated in vacuo. The resultant residue is purified by reverse phase preparative HPLC to give the title product, M+H 427, retention time 7.92 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06706757B2 |
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| 출처 데이터셋 | uspto-grants-2004_03 |
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| ORD ID | ord-b252316eb42d4f76a074015cae6cf308 |
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| 출처 메모 | uspto-grants-2004_03 |
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