Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Dimethyl-4-hydroxybenzonitrile → Win 58768
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Dimethyl-4-hydroxybenzonitrile | HCID 20176 | — |
| 반응물 | Win 58768 | HCID 148372 | — |
| 반응물 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 반응물 | 6-n-Propyl-3-(4-hydroxy-1-piperidinyl)pyridazine | HCID 19797304 | — |
| 생성물 | Win 58768 | HCID 148372 | — |
| 생성물 | (3,5-dimethyl-4-hydroxyphenyl)-2H-tetrazole | HCID 86747187 | — |
반응 단계
2-Methyl-5-((3,5-dimethyl-4-hydroxyphenyl)-2H-tetrazole (Formula III: R2 =R3 =R4 =CH3) was prepared according to the procedure of Example 1b starting with 2,6-dimethyl-4-cyanophenol. 4.5 Mmol of 6-methyl-3-(4-hydroxyl-1-piperidinyl)pyridazine (Formula IV: R1 =methyl, Y=CH2), 1.14 g DEAD, 6.8 mmol TPP, 5 mmol of 2-methyl-5-(3,5-dimethyl-4-hydroxyphenyl)-2H-tetrazole (Formula III: R2 =R3 =R4 =CH3) were reacted as described in Example 1c. Recrystallization from ethyl acetate afforded a 71.9% yield of the compound of Formula I (R1 =R2 =R3 =R4 =methyl, Y=CH2) m.p. 183°-184° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05242924 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-497fa056f7bb46efa7e51c283e600987 |
| 출처 메모 | uspto-grants-1993_09 |