4-Bromophenyl chloroformate → 6-(4-Diethylamino-butoxy)-3,4-dihydro-2H-quinoline-1-carboxylic acid 4-bromo-phenyl ester

HRID 49487

반응식

HRID 49487 반응식
[CH2:1]([N:3]([CH2:19][CH3:20])[CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[NH:15][CH2:14][CH2:13][CH2:12]2)[CH3:2].Cl[C:22]([O:24][C:25]1[CH:30]=[CH:29][C:28]([Br:31])=[CH:27][CH:26]=1)=[O:23]>>[Br:31][C:28]1[CH:29]=[CH:30][C:25]([O:24][C:22]([N:15]2[C:16]3[C:11](=[CH:10][C:9]([O:8][CH2:7][CH2:6][CH2:5][CH2:4][N:3]([CH2:1][CH3:2])[CH2:19][CH3:20])=[CH:18][CH:17]=3)[CH2:12][CH2:13][CH2:14]2)=[O:23])=[CH:26][CH:27]=1

참가 물질

3

반응물 2

HCID 52377364-Bromophenyl chloroformateHCID 21966664Diethyl-[4-(1,2,3,4-tetrahydro-quinolin-6-yloxy)-butyl]-amine

생성물 1

HCID 695147076-(4-Diethylamino-butoxy)-3,4-dihydro-2H-quinoline-1-carboxylic acid 4-bromo-phenyl ester

실험 절차

In analogy to example 3.9, Diethyl-[4-(1,2,3,4-tetrahydro-quinolin-6-yloxy)-butyl]-amine and 4-bromophenyl chloroformate were converted to yield 6-(4-Diethylamino-butoxy)-3,4-dihydro-2H-quinoline-1-carboxylic acid 4-bromo-phenyl ester as colorless oil, MS: 475 (MH+, 1Br).

출처 및 근거

ORD 기록
ord-46d785392e104f26bc9e01a0e536fcdd
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706751B2

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