N-methyl-1-(1-benzyloxycarbonylpiperidin-4-yl)-1H-indole-6-carboxamide → 1-(piperidin-4-yl)-N-methyl-1H-indole-6-carboxamide

HRID 494915노트

반응식

HRID 494915 반응식
[CH3:1][NH:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([CH:9]=[CH:10][N:11]2[CH:14]2[CH2:19][CH2:18][N:17](C(OCC3C=CC=CC=3)=O)[CH2:16][CH2:15]2)=[CH:7][CH:6]=1)=[O:4].[H][H]>CO.[C].[Pd]>[CH3:1][NH:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([CH:9]=[CH:10][N:11]2[CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:7][CH:6]=1)=[O:4]

참가 물질

5

반응물 2

HCID 57682860N-methyl-1-(1-benzyloxycarbonylpiperidin-4-yl)-1H-indole-6-carboxamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 576828371-(piperidin-4-yl)-N-methyl-1H-indole-6-carboxamide수율 83.6%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매2회HCID 887Methanol용매

실험 절차

1.77 g of N-methyl-1-(1-benzyloxycarbonylpiperidin-4-yl)-1H-indole-6-carboxamide was dissolved in 30 ml of methanol. Then, 200 mg of 10% palladium carbon was added to the obtained solution. The reaction atmosphere was replaced by hydrogen, and it was then stirred at room temperature. After completion of the reaction, 10% palladium carbon was filtered off from the reaction solution, and the reaction solution was then concentrated under a reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate/methanol), followed by solidification from a mixed solution consisting of ethyl acetate, t-butylmethyl ether, and methanol, so as to obtain 973 mg of the subject compound.

후처리

  1. customThe reaction atmosphere
  2. filtrationwas filtered off from the reaction solution
  3. concentrationthe reaction solution was then concentrated under a reduced pressure
  4. customThe residue was purified by NH silica gel column chromatography (ethyl acetate/methanol)

출처 및 근거

ORD 기록
ord-300aff1a8c3347148e59f89c6d1fa17c
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538123B2

반응 노트

불러오는 중…