Potassium Carbonate → 5-(4-Bromo-but-2-enyloxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	N-Boc-5-Hydroxyindoline	HCID 10657398	—
반응물	1,4-Dibromobut-1-ene	HCID 53629311	—
용매	Water	HCID 962	—
용매	Diethyl Ether	HCID 3283	—
용매	Dimethylformamide	HCID 6228	—
생성물	5-(4-Bromo-but-2-enyloxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester	HCID 69515078	31.9%

반응 조건

온도	50 °C

반응 단계

514 mg (2.3 mmol) 5-Hydroxy-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester in 12 ml DMF were treated with 830 mg (6 mmol) powdered K2CO3 and 1070 mg (5 mmol) 1,4-dibromobutene. The suspension was stirred at 50° C. for 3 h, cooled to RT, diluted with ether and water. The aqueous phase was extracted with ether, the organic phases were washed with water and dried over Na2SO4. Column chromatography on silica gel with hexane/EtOAc 9:1 yielded 270 mg (31%) 5-(4-Bromo-but-2-enyloxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester as colorless solid, MS: 368 (MH+, 1Br).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06706751B2
출처 데이터셋	uspto-grants-2004_03
ORD ID	ord-191c59b28e964af6a3cd91ce94ab1f94
출처 메모	uspto-grants-2004_03