홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Bicarbonate → 1-(1-(2-(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl)piperidin-4-yl)-1H-indole-6-carboxamide

HRID 494945
노트
인쇄 미리보기

반응식

HRID 494945 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:16]([NH2:18])=[O:17])[CH:14]=3)[CH:9]=[CH:8]2)[CH2:3][CH2:2]1.[CH3:19][O:20][C:21]1[C:30]([CH2:31][CH:32]=O)=[C:29]2[C:24]([C:25](=[O:36])[CH2:26][C:27]([CH3:35])([CH3:34])[O:28]2)=[CH:23][CH:22]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C(=O)(O)[O-].[Na+]>C(Cl)Cl.C(O)(=O)C>[CH3:19][O:20][C:21]1[C:30]([CH2:31][CH2:32][N:1]2[CH2:2][CH2:3][CH:4]([N:7]3[C:15]4[C:10](=[CH:11][CH:12]=[C:13]([C:16]([NH2:18])=[O:17])[CH:14]=4)[CH:9]=[CH:8]3)[CH2:5][CH2:6]2)=[C:29]2[C:24]([C:25](=[O:36])[CH2:26][C:27]([CH3:35])([CH3:34])[O:28]2)=[CH:23][CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 516892Sodium BicarbonateHCID 5049666Sodium triacetoxyborohydrideHCID 57682772(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehydeHCID 576827861-(piperidin-4-yl)-1H-indole-6-carboxamide

생성물 1

HCID 116772571-(1-(2-(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl)piperidin-4-yl)-1H-indole-6-carboxamide수율 93.8%

시약·촉매·용매

2
HCID 176Acetic Acid용매HCID 6344Dichloromethane용매

실험 절차

120 mg of 1-(piperidin-4-yl)-1H-indole-6-carboxamide and 163 mg of (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde were dissolved in 10 ml of methylene chloride. Thereafter, 0.06 ml of acetic acid was added to the reaction solution, and the obtained mixture was then stirred at room temperature for 15 minutes. Thereafter, 157 mg of sodium triacetoxyborohydride was added to the reaction solution, and the obtained mixture was then stirred at room temperature for 1 hour. Thereafter, a saturated sodium bicarbonate aqueous solution was added to the reaction solution, followed by extraction with chloroform. The extract was dried over magnesium sulfate and then concentrated under a reduced pressure. The residue was purified by NH silica gel column chromatography (methanol-ethyl acetate), followed by solidification with ethyl acetate, so as to obtain 220 mg of the subject compound.

후처리

  1. stirringthe obtained mixture was then stirred at room temperature for 1 hour
  2. extractionfollowed by extraction with chloroform
  3. dry with materialThe extract was dried over magnesium sulfate
  4. concentrationconcentrated under a reduced pressure
  5. customThe residue was purified by NH silica gel column chromatography (methanol-ethyl acetate)

출처 및 근거

ORD 기록
ord-3c2b93f24f674912b34e708dc15424bd
출처 데이터셋
uspto-grants-2009_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07538123B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트