Methanol → HCID 57682769, 화합물

HRID 494999노트

반응식

HRID 494999 반응식
CO.O1CCCC1.C([O:15][C:16]1[C:21]([C:22]([NH:24][CH3:25])=[O:23])=[CH:20][CH:19]=[C:18]([O:26][CH3:27])[C:17]=1[CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][CH:33]([N:36]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([C:45]([NH2:47])=[O:46])[CH:43]=3)[CH:38]=[CH:37]2)[CH2:32][CH2:31]1)C1C=CC=CC=1>[Pd]>[OH:15][C:16]1[C:21]([C:22]([NH:24][CH3:25])=[O:23])=[CH:20][CH:19]=[C:18]([O:26][CH3:27])[C:17]=1[CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][CH:33]([N:36]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([C:45]([NH2:47])=[O:46])[CH:43]=3)[CH:38]=[CH:37]2)[CH2:32][CH2:31]1

참가 물질

5

반응물 3

HCID 887MethanolHCID 8028TetrahydrofuranHCID 57682824HCID 57682824, 화합물

생성물 1

HCID 57682769HCID 57682769, 화합물수율 100.7%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

15 ml of methanol and 10 ml of tetrahydrofuran were added to and dissolved in 486 mg of 1-(1-(2-(2-(benzyloxy)-6-methoxy-3-((methylamino)carbonyl)phenyl)ethyl)piperidin-4-yl)-1H-indole-6-carboxamide. Thereafter, 74 mg of 10% Pd—C (containing water) was added thereto, and the obtained mixture was then stirred at room temperature under hydrogen atmosphere overnight. Thereafter, Pd—C was removed by filtration, and the solvent was removed under a reduced pressure, so as to obtain 408 mg of the subject compound.

후처리

  1. customThereafter, Pd—C was removed by filtration
  2. customthe solvent was removed under a reduced pressure

출처 및 근거

ORD 기록
ord-91cafb84c28b4cf8b1577b4afd28299c
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538123B2

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