4-(2-methyl-1H-imidazol-1-yl)aniline → 4-methyl-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

참여 물질

역할	이름	HCID	투입량
반응물	4-(2-methyl-1H-imidazol-1-yl)aniline	HCID 3157478	—
반응물	8-Chloro-4-methyl-2-phenyl-3,4-dihydropyrido[3,2-F][1,4]oxazepin-5(2H)-one	HCID 59577825	—
시약	Cesium carbonate	HCID 10796	—
촉매	2-(Dicyclohexylphosphino)biphenyl	HCID 2734216	—
촉매	Palladium (II) acetate	HCID 4144353	—
용매	1,2-Dimethoxyethane	HCID 8071	—
생성물	4-methyl-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one	HCID 49820084	42.31%

반응 조건

온도	100 °C

반응 단계

were placed in a microwave vial equipped with a stirring bar. The vial was capped and flushed with argon. DME (2 mL) was added via a syringe and the mixture was heated to 100°C in a microwave apparatus for 1h. The reaction mixture was filtered, the solvent was evaporated and the residue was purified by HPLC to give 53 mg (42 % yield) of the product as a solid.

출처 및 근거

출처 데이터셋	750 AstraZeneca ELN dataset
ORD ID	ord-1df95b34548d48fe94a49234436e46e5
출처 메모	750 AstraZeneca ELN dataset