Acetone → DN9H25S82Z

HRID 495012노트

반응식

HRID 495012 반응식
[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:35])([CH3:34])[O:10]2)=[CH:5][CH:4]=1.[C:37]([OH:44])(=[O:43])/[CH:38]=[CH:39]/[C:40]([OH:42])=[O:41].CC(C)=O>O>[C:37]([OH:44])(=[O:43])/[CH:38]=[CH:39]/[C:40]([OH:42])=[O:41].[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:34])([CH3:35])[O:10]2)=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 180AcetoneHCID 444972Fumaric AcidHCID 11677552E-2110 free base

생성물 1

HCID 16038980DN9H25S82Z수율 88.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (1.00 g) and fumaric acid (0.249 g) were dissolved in a mixed solvent consisting of acetone (5 ml) and water (15 ml) at 60° C. Thereafter, the reaction solution was left at room temperature for 1 hour. The deposited solid was collected by filtration. The collected crystal was washed with a mixed solvent consisting of acetone (2.5 ml) and water (7.5 ml), so as to obtain the subject compound (1.09 g).

후처리

  1. filtrationThe deposited solid was collected by filtration
  2. washThe collected crystal was washed with a mixed solvent

출처 및 근거

ORD 기록
ord-48dabf7afe454b079a0ee41939b4ecb5
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538123B2

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