[CH2:1]([C:3]1([OH:18])[C:13]2[C:8](=[C:9]([O:15]C)[N:10]=[C:11]([I:14])[CH:12]=2)[CH2:7][O:6][C:5](=[O:17])[CH2:4]1)[CH3:2].[I-].[Na+].Cl[Si](C)(C)C.O.[O-]S([O-])=O.[Na+].[Na+].[Cl-].[Na+].O>C(#N)C>[CH2:1]([C:3]1([OH:18])[C:13]2[CH:12]=[C:11]([I:14])[NH:10][C:9](=[O:15])[C:8]=2[CH2:7][O:6][C:5](=[O:17])[CH2:4]1)[CH3:2]
To a flame dried flask was added iodolactone (8) (0.33 g, 0.90 mmol) followed by dry acetonitrile (12 mL). Sodium iodide (0.22 g, 1.44 mmol) was added followed by chlorotrimethylsilane (0.18 mL, 1.44 mmol). The resulting mixture was stirred at 22° C. for 15 minutes at which point H2O (7.6 μL, 0.42 mmol) was added and the mixture was heated at 60° C. After 5 hours at 60° C. the mixture was poured into a 1:1 solution of 50 Na2SO3/Brine (75 mL) and then quickly extracted with EtOAc (6×75 mL). The organic layer was dried (MgSO4) and chromatographed (CH2Cl2:MeOH 95:5) to yield iodopyridone (9) as a white solid 0.19 g (61%): 1H NMR (300 MHz, CDCl3/CD3OD) δ 0.62 (t, J=7 Hz, 3 H), 1.45-1.54 (m, J=7 Hz, 2 H), 2.80 (d, J=14 Hz, 1 H), 2.97 (d, J=14 Hz, 1 H), 4.93 (d, J=15 Hz, 1 H), 5.06 (d, J=15 Hz, 1 H), 6.66 (s, 1 H); 13C NMR (75 MHz, CDCl3) δ 7.5, 35.6, 41.9, 61.6, 72.5, 94.4, 118.3, 121.1, 156.5, 162.6, 172.7; HRMS (EI) m/z calcd for C11H12INO4 (M+) 348.9811, found 348.9815 LRMS (EI) m/z 349 (M+), 331, 320, 303, 289, 278, 264, 250, 162, 150, 122, 94, 57.
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