Carbon Dioxide → 2-Phenylisobutyric acid

HRID 495109

반응식

HRID 495109 반응식
[CH3:1][C:2]1([CH3:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=O)[CH2:3]1.[C:13]1([C:19]([CH3:24])([CH3:23])[C:20]([OH:22])=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH2:25](Cl)[C:26]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)(C)[CH3:27].[Mg].C(=O)=O>>[C:13]1([C:19]([CH3:24])([CH3:23])[C:20]([OH:22])=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH3:25][C:26]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)([CH2:4][CH2:3][C:2]([CH3:1])([C:10]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:12])[CH3:27]

참가 물질

7

반응물 5

HCID 280Carbon DioxideHCID 132222-Phenylisobutyric acid2회HCID 68191Neophyl chlorideHCID 3046283,3-Dimethyl-1-indanoneHCID 5462224Magnesium

생성물 2

HCID 132222-Phenylisobutyric acidHCID 3167052,5-Dimethyl-2,5-diphenylhexane

실험 절차

A convenient synthesis into 3,3-dimethyl indan-1-one is via the acid catalysed cyclisation of phenylisobutyric acid. The phenylisobutyric acid may be prepared by reaction of neophylchloride with magnesium followed by carbon dioxide under known conditions. Typically, one obtains phenylisobutyric acid in admixture with an unwanted coupling product 2,5-dimethyl-2,5-diphenyl hexane.

출처 및 근거

ORD 기록
ord-e9d2482638e5442e8234f0af31d5e552
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538243B2

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