Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorobutyryl chloride → 1,4-Benzodioxan
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorobutyryl chloride | HCID 78370 | — |
| 반응물 | Ethyl indole-5-carboxylate | HCID 10987040 | — |
| 반응물 | 3-(4-Aminobutyl)-5-ethoxycarbonylindole | HCID 19797347 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1,4-Benzodioxan | HCID 10301 | — |
| 생성물 | 3-(4-Chlorobutyl)-5-ethoxycarbonylindole | HCID 19438863 | — |
| 생성물 | 3(4-Phthalimidobutyl)-5-ethoxycarbonylindole | HCID 19797343 | — |
반응 단계
A mixture of 2.18 g of 3-(4-aminobutyl)-5-ethoxycarbonylindole [obtainable from 5-ethoxycarbonylindole by reaction with 4-chlorobutyryl chloride, reduction of the product to give 3-(4-chlorobutyl)-5-ethoxycarbonylindole and conversion into 3(4-phthalimidobutyl)-5-ethoxycarbonylindole] and one equivalent of 6-N,N-bis(2-chloroethyl)amino)-1,4-benzodioxane ("B") in 40 ml of acetone and 40 ml of water is boiled for 24 hours and worked up in the conventional manner. 6-[4-(4-(5-ethoxycarbonylindol-3-yl)butyl)piperazino]-1,4-benzodioxane is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05242925 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-cd278516758a47cb98650ef6509a3367 |
| 출처 메모 | uspto-grants-1993_09 |