Sulfuric Acid → 1-Isoquinolinyloxyacetaldehyde
반응식
C[O:2][C:3](OC)([O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][N:7]=1)[CH3:4].O1CCOCC1.S(=O)(=O)(O)O>O>[C:6]1([O:5][C:3](=[O:2])[CH3:4])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][N:7]=1참가 물질
5
반응 조건
- 온도
- 85 °C
실험 절차
A mixture of 1-isoquinolinyloxyacetaldehyde dimethyl acetal (0.93 g, 4 mmol), dioxane (10 mL), water (15 mL) and conc. sulfuric acid (2 mmol) was heated at 85° C. for 2 h, then was quenched with saturated aqueous sodium hydrogen carbonate (100 mL). The resulting mixture was extracted with dichloromethane (2×100 mL) and the combined organic extracts were washed with saturated aqueous sodium hydrogen carbonate (50 mL), dried over sodium sulfate and evaporated in vacuo to give the title compound (0.43 g, 57%).
후처리
- customwas quenched with saturated aqueous sodium hydrogen carbonate (100 mL)
- extractionThe resulting mixture was extracted with dichloromethane (2×100 mL)
- washthe combined organic extracts were washed with saturated aqueous sodium hydrogen carbonate (50 mL)
- dry with materialdried over sodium sulfate
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-c65813df7712480da7f56b4b9f71f2eb
- 출처 데이터셋
- uspto-grants-2005_09
- 특허 번호
- US06939871B2
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