Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethylene Glycol Monoethyl Ether → 6-[4-(4-(5-Carbamoylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethylene Glycol Monoethyl Ether | HCID 8146 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 6-[4-(4-(5-Cyanobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797317 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-[4-(4-(5-Carbamoylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797326 | — |
반응 단계
A mixture of 4.16 g of 6-[4-(4-(5-cyanobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane, 2.4 g of NaOH, 50 ml of H2O and 40 ml of diethylene glycol monoethyl ether is stirred at a bath temperature of 140° for 3 hours. The mixture is then cooled to room temperature, worked up in the conventional manner and gives 6-[4-(4-(5-carbamoylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05242925 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-a782508ad5da4e58a935bed7bb6cedd1 |
| 출처 메모 | uspto-grants-1993_09 |