Picolinoyl Chloride Hydrochloride → 4-[2-({4-[[3-(4-Chlorophenyl)propyl](methyl)amino]-6-[4-(2-pyridinylcarbonyl)-1-piperazinyl]-1,3,5-triazin-2-yl}amino)ethyl]phenol

참여 물질

역할	이름	HCID	투입량
반응물	Picolinoyl Chloride Hydrochloride	HCID 135033	—
반응물	4-(2-{[4-[[3-(4-Chlorophenyl)propyl](methyl)amino]-6-(1-piperazinyl)-1,3,5-triazin-2-yl]amino}ethyl)phenol	HCID 10299557	—
용매	Dichloromethane ethyl acetate methanol	HCID 21901258	—
생성물	4-[2-({4-[[3-(4-Chlorophenyl)propyl](methyl)amino]-6-[4-(2-pyridinylcarbonyl)-1-piperazinyl]-1,3,5-triazin-2-yl}amino)ethyl]phenol	HCID 10145060	46%

반응 단계

The title compound was prepared in 46% yield via the procedure outlined for Example 3 using 4-(2-{[4-[[3-(4-chlorophenyl)propyl](methyl)amino]-6-(1-piperazinyl)-1,3,5-triazin-2-yl]amino}ethyl)phenol and picolinoyl chloride hydrochloride to give a white glass: 1H NMR (CDCl3, 300 MHz) δ 8.65 (bs, 1H), 7.83 (t, 1H, J=7.5), 7.72 (d, 1H, J=7.5), 7.40 (t, 1H, J=5.7), 7.24-7.21 (m, 2H), 7.12-7.04 (m, 4H), 6.73 (d, 2H, J=8.1), 3.96-3.78 (m, 4H), 3.75-3.55 (m, 6H), 3.10 (s, 3H), 2.80 (t, 2H, J=6.6), 2.65-2.60 (m, 2H), 1.95-1.89 (m, 2H); low resolution MS (ES+) m/e 588 (MH+); TLC (CH2Cl2/EtOAc/MeOH (5:5:1)): Rf=0.62.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06943162B2
출처 데이터셋	uspto-grants-2005_09
ORD ID	ord-3a131a92e5cf41879452c243cafb2e79
출처 메모	uspto-grants-2005_09