Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nitrogen → 6-[4-(4-(5-Hydroxymethylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nitrogen | HCID 947 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 6-[4-(4-(5-Methoxycarbonylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797327 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 6-[4-(4-(5-Hydroxymethylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797328 | — |
반응 단계
A solution of 4.4 g of 6-[4-(4-(5-methoxycarbonylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane in 40 ml of THF is added dropwise with stirring in an N2 atmosphere at 20° to a suspension of 0.6 g of lithium aluminium hydride in 20 ml of THF. The mixture is stirred at 20° for 1 hour, decomposed with dilute sodium hydroxide solution and filtered, and the filtrate is worked up in the conventional manner and gives 6-[4-(4-(5-hydroxymethylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05242925 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-22a8f936264443019aa427698e2e3d90 |
| 출처 메모 | uspto-grants-1993_09 |