참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6-Nitro-m-cresol | HCID 12788 | — |
| 촉매 | Epibromohydrin | HCID 18430 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Oxirane, ((5-methyl-2-nitrophenoxy)methyl)- | HCID 153034 | 83% |
반응 단계
A mixture of 5-Methyl-2-nitrophenol (7.7 g, 50 mmol), potassium carbonate (13.8 g, 0.1 mmol) and epibromohydrine (8.25 mL, 0.1 mmol) was dissolved in DMF (100 mL) and stirred 2-3 h at 100° C. under an atmosphere of nitrogen. The mixture was diluted with ether (0.5L) and extracted with water until pH=7. The organic phase was evaporated and the residue was purified by flash-chromatography on silica (DCM) to give the sub-title compound as a yellow solid (8.65 g, 83%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06943188B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_09 |
|---|
| ORD ID | ord-fb52fea343044fd4b0211f5acc6755f7 |
|---|
| 출처 메모 | uspto-grants-2005_09 |
|---|
