Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Bromoacetonitrile | HCID 11534 | — |
| 반응물 | 4-(Naphth-1-yl)piperidine hydrobromide | HCID 19096220 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | (4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride | HCID 19784336 | 91.83% |
반응 단계
5 g of the compound from Example 3, 7.088 g of potassium carbonate and 2.259 g of bromoacetonitrile in 200 ml of acetone are stirred for 10 hours under reflux and a stream of nitrogen. After filtering and evaporation of the filtrate, the residue obtained is treated with an ethanolic solution of hydrogen chloride to give 4.5 g of the expected hydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05242933 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-c23b7acaed9b4fbbb249c32c51607fe4 |
| 출처 메모 | uspto-grants-1993_09 |