Methanol → Methyl 2-Bromo-4-nitrobenzoate

반응식

[Br:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:14]O>>[Br:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:14])=[O:5]

참가 물질

반응물 2

HCID 887Methanol

HCID 3135342-Bromo-4-nitrobenzoic acid

생성물 1

HCID 15833211Methyl 2-Bromo-4-nitrobenzoate

실험 절차

Compound 26 in methanol was treated with SO2Cl2 and the resulting solution heated at reflux for18 h. The reaction mixture was then evaporated, pre-absorbed on silica (Merck, 9385) and purified by chromatography, eluting with 10% ethyl acetate/i-hexane. Appropriate fractions were combined and evaporated to give methyl 2-bromo-4-nitro-benzoate (compound 27).

후처리

temperaturethe resulting solution heated
temperatureat reflux for18 h
customThe reaction mixture was then evaporated
custompre-absorbed on silica (Merck, 9385)
custompurified by chromatography
washeluting with 10% ethyl acetate/i-hexane
customevaporated

출처 및 근거

ORD 기록: ord-dff9c183e7ac4755bae7a188497d9847
출처 데이터셋: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06946468B1

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